NAD+: Energy Metabolism, Redox Biology & Cellular Repair Research

9 Feb 2026

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to virtually all metabolic processes. Its role in energy transfer, redox cycling and cellular repair pathways makes it indispensable in biochemical and ageing research. Although NAD+ has gained popularity in discussions related to human health, all NAD+ supplied by Euro-Gen is strictly for research use.

Core Biological Role

NAD+ functions as an electron carrier in metabolic pathways. The ratio of NAD+ to its reduced form (NADH) is essential for:

  • ATP production
  • Glycolysis
  • Oxidative phosphorylation
  • Fatty acid oxidation
  • Redox homeostasis

Its involvement across thousands of enzymatic reactions makes NAD+ one of the most important molecules in cell biology.

Mitochondrial Research

Mitochondria depend heavily on NAD+ availability. Researchers use NAD+ to study:

  • Mitochondrial respiration efficiency
  • Electron transport chain behaviour
  • Metabolic dysfunction
  • Reactive oxygen species regulation

Because mitochondrial decline is linked to ageing, NAD+ remains a focal point in longevity research.

DNA Repair & PARP Signalling

One of NAD+'s most significant functions involves serving as a substrate for PARP enzymes (poly ADP-ribose polymerases). These enzymes play a key role in:

  • DNA strand break repair
  • Chromatin remodelling
  • Genomic stability maintenance
  • Stress response signalling

When DNA damage increases, PARP enzymes consume NAD+ rapidly, making it a central molecule in genomic health research.

Sirtuin Activation & Metabolic Pathways

NAD+ is also essential for the activation of sirtuin enzymes — a family of proteins associated with metabolic regulation and cellular stress resilience.

Research uses NAD+ to investigate:

  • SIRT1 activation and metabolic signalling
  • Cellular protection mechanisms
  • Stress response pathways
  • Links between nutrient sensing and ageing

These studies often explore potential implications for human physiology while remaining firmly experimental.

NAD+ in Human Research Models

Many modern studies explore NAD+ in the context of:

  • Age-related metabolic decline
  • Neurodegeneration models
  • Muscle energy systems
  • Immunometabolic pathways

Such research aims to deepen scientific understanding but does not imply approved therapeutic use.

Compliance Reminder

All NAD+ products from Euro-Gen are strictly for laboratory use and not approved for human consumption.

Conclusion

NAD+ continues to be one of the most influential molecules in metabolism and ageing research, fueling discoveries across energy production, DNA repair and redox biology.